ECM Graft® SEM Image
Cartilage cells grown on Porous Microcarrier PMc®
Stromal Cells grown on Dot-Cult®

ExCel Matrix Biological Devices (P) Ltd.

Whitepapers

An ability to control cell function is the “Holy Grail”
3D cell culture is the first step towards it

Regenerative medicine seeks functionally viable cells to be delivered at the site of injury besides the need of restoring tissue/organ shape through artificial scaffolds. Cells cultured by conventional methods that allow only two-dimensional growth are not the true representatives of cells growing in vivo. Cells are dynamically related to their surrounding environment that incorporates both cellular and extra-cellular milieu. The density of extra-cellular matrix (ECM) varies from tissue to tissue depending upon the tissue specific proteins and glyocoproteins that orchestrate it. Comprehension of Cell-ECM dynamics is an important aspect for recreating functional tissue ex vivo1. However, one of the fundamental needs to develop this understanding is to allow cells to grow in three-dimensional scaffold. An optimally designed scaffold matrix can have enumerable research and therapeutic applications2.

  1. Ranjna C. Dutta and Aroop K. Dutta. Comprehension of ECM-Cell dynamics: A prerequisite for tissue regeneration. Biotechnology Advances 28 (2010) 764-769.
  2. Ranjna C. Dutta and Aroop K. Dutta. Cell-interactive 3D-scaffold; advances and applications. Biotechnology Advances 27 (2009) 334–339.